Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free)
Integrin alpha-V, Vitronectin receptor subunit alpha, CD51, 1.Integrin alpha-V heavy chain2.Integrin alpha-V light chain, Integrin alphaV
产品介绍９/div>
产品说明
一般描?/p>
Integrin alphaV, also known as CD51, a member of the integrin family, is a 140 kD protein expressed on activated T cells, polymorphonuclear granulocytes, blastocysts, and osteoclasts. Integrin alphaV forms heterodimers by association with integrins beta1, beta3, beta5 or beta6, these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The alphaV integrins have varied functions in development, stimulation/activation and homeostasis. The primary ligands for Integrin alphaV complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31.
特异?/p>
Specifically recognizes Integrin alphaV, also known as CD51 or vitronectin receptor. This antibody has been reported to block binding of Integrin alphaV to vitronectin, fibronectin, fibrinogen, and CD31 in some cell types, as well as, blocking LAK cell cytotoxicity.
免疫厞/p>
BALB/c mouse IL-2Cactivated killer (LAK) cells
应用
This Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free) is validated for use in Western Blotting, Immunoprecipitation, Flow Cytometry for the detection of mouse Integrin alphaV.
Western Blot Analysis: A representative lot was used by an independent laboratory in LAK cell lysate. (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in LAK cell lysate. (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)
Blocking Assay: Adhesion and LAK cell cytotoxicity was shown using a representative lot (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)
质量
Evaluated by Flow Cytometry in murine 3T3-L1 cells.
Flow Cytometry Analysis: 0.2 ?g of this antibody detected Integrin alphaV in murine 3T3-L1 cells .
目标描述
~140 kDa observed. The calculated molecular weight is 115 kDa, however Integrin alphaV has been shown as a ~140 kDa band in western blots (Takahashi, K. et al., (1990). J. Immunol. 145:4371.).
联系
Replaces: CBL1346Z
外形
Format: Purified
Protein G Purified
分析说明
Control
Murine 3T3-L1 cells
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss |
32160702 |
| NACRES |
NA.41 |
产品性质
| 质量水平 |
100 |
| 生物来源 |
rat |
| 抗体形式 |
purified immunoglobulin |
| antibody product type |
primary antibodies |
| 克隆 |
RMV-7, monoclonal |
| species reactivity |
mouse |
| technique(s) |
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable |
| 同位?亚型 |
IgG1 |
| NCBI登记叶/td> |
NP_032428 |
| UniProt登记叶/td> |
P43406 |
| 运输 |
dry ice |
安全信息
| 储存分类代码 |
12 - Non Combustible Liquids |
| WGK |
WGK 2 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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