Monoclonal Anti-Intracellular Adhesion Molecule 3 antibody produced in mouse

产品说明

一般描�?/p>

The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.

免疫厞�/p>

stimulated human leukocytes.

生化/生理作用

The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.

外形

Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.

基本信息

MDL编号	MFCD01094485
NACRES	NA.41

产品性质

质量水平	200
生物来源	mouse
偶联�?/td>	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	186-2G9, monoclonal
形式	buffered aqueous solution
分子野�/td>	antigen 120 kDa
species reactivity	human
浓度	~1 mg/mL
technique(s)	direct immunofluorescence: 2 ��g using 1 mg protein lysate flow cytometry: 2 ��g using 1 mg protein lysate immunohistochemistry: 2-4 ��g/mL using human tonsil tissue sections immunoprecipitation (IP): 2 ��g using 1 mg protein lysate western blot: 1-5 ��g/mL
UniProt登记叶�/td>	P32942
运输	wet ice
储存温度	?20ℂ�/td>
Gene Information	human ... ICAM3(3385)