产品介绍９/div>
产品说明
一般描?/p>
Integrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
免疫厞/p>
Purified human 1 Integrin preparation from HT1080 fibrosarcoma cell extract
应用
Research Category
Cell Structure
Western Blot Analysis: 0.5 ?g/mL from a representative lot detected Integrin 1 in 10 ?g of Integrin purified protein.
Immunofluorescence Analysis: A representative lot was used in an independent laboratory in mouse lung tissue. (Chen P., et al. (2009). PLoS ONE. 4(8):e6565.)
This Anti-Integrin 1 Antibody, clone 12G10 is validated for use in Western Blotting, Flow Cytometry, Immunofluorescence for the detection of Integrin 1.
Research Sub Category
ECM Proteins
质量
Evaluated by Flow Cytometry in HeLa cells.
Flow Cytometry Analysis: 1 ?g of this antibody detected Integrin 1 in HeLa cells.
目标描述
~192 kDa observed
联系
Replaces: MAB2247
外形
Purified mouse monoclonal IgG1 in PBS containing 0.1% sodium azide.
Format: Purified
Protein G Purified
储存及稳定?/p>
Stable for 1 year at 2-8C from date of receipt.
分析说明
Control
HeLa cells
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss |
32160702 |
| NACRES |
NA.41 |
产品性质
| 质量水平 |
100 |
| 生物来源 |
mouse |
| 抗体形式 |
purified immunoglobulin |
| antibody product type |
primary antibodies |
| 克隆 |
12G10, monoclonal |
| species reactivity |
human |
| technique(s) |
flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable |
| 同位?亚型 |
IgG1 |
| NCBI登记叶/td> |
NM_002211 |
| UniProt登记叶/td> |
P05556 |
| 运输 |
wet ice |
| Gene Information |
human ... ITGB1(3688) |
安全信息
| 储存分类代码 |
10 - Combustible liquids |
| WGK |
WGK 2 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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