产品介绍９/div>
产品说明
一般描?/p>
Recombinant human IL28 is expressed in HEK 293 cells with a calculated molecular mass of ~20 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like folding, and often supports better stability of the protein in culture. The protein is produced with no artificial tags.
生化/生理作用
IL28 is a newly-discovered type III interferon, with antiviral, antiproliferative, and immunomodulatory functions. Type III IFNs share homology with IL-10 and the IL-10R2 receptor subunit, leading to the speculation that these cytokines might be evolutionarily related. It was recently found that polymorphisms in IFN-lambda-4 (another type III interferon) are associated with circulating IL28, and higher plasma IL28 are associated with higher production of antibodies to HBV surface antigen. IL28 is associated with the extent of lupus activity, in particular with active serosal and cutaneous disease. Combined treatment with IL28 and sorafenib (a small molecule multikinase inhibitor) facilitates a synergistic effect on suppressing hepatocellular carcinoma cancer growth and promoting cell apoptosis in vitro and in vivo.
产品性质
| 重组 |
expressed in HEK 293 cells |
| 测定 |
95% (SDS-PAGE) |
| 形式 |
lyophilized powder |
| 效能 |
1 ng/mL EC50(measured in a viral resistance assay) |
| technique(s) |
cell culture | mammalian: suitable |
| 杂质 |
Endotoxin, tested |
| 储存温度 |
?20ℂ/td> |
安全信息
| 储存分类代码 |
13 - Non Combustible Solids |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
m.cnreagent.com
