Monoclonal Anti-Dynamin 2 (DNM2) antibody produced in mouse

Monoclonal Anti-Dynamin 2 (DNM2) antibody produced in mouse
CMTDIB
CMTDI1
dynamin 2
DI-CMTB
DYN2
LCCS5
DYNII
CMT2M

产品介绍９�/div>

产品说明

一般描�?/p>

Monoclonal Anti-Dynamin 2 (DNM2) (mouse IgG1 isotype) is derived from the hybridoma DYN2-11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Dynamin 2 (DNM2) also known as DYN2 belongs to the dynamins family of guanosine triphosphatase (GTPase) proteins.
The gene DNM2 (dynamin 2) is mapped to human chromosome 19p13. It is widely expressed. The protein has a catalytic amino-terminal GTPase domain, a middle domain, a pleckstrin homology domain (PH), a GTPase effector domain (GED) and a less conserved carboxyl-terminal proline/arginine rich domain (PRD).

免疫厞�/p>

synthetic peptide corresponding to a sequence at the N-terminal region of human DNM2 , conjugated to KLH

应用

Monoclonal Anti-Dynamin 2 (DNM2) antibody produced in mouse has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生化/生理作用

Furthermore, DNM2 is upregulated in pancreatic cancer as it activates Ras-related C3 botulinum toxin substrate 1 (Rac1). It also promotes invasive cellular migration and lamellipod protrusion.
DNM2 (dynamin 2) is a GTPase which is required for clathrin-mediated endocytosis. It is important for clathrin-coated pit maturation and clathrin-coated vesicle formation. DNM2 participates in neuronal morphology, axonal growth, centrosome cohesion, actin- and microtubular organization. Mutations in it are associated with Charcot-Marie-Tooth disease, centronuclear myopathy ADCNM (autosomal dominant centronuclear myopathy) and lethal congenital contractures syndrome type 5 (LCCS5). It is upregulated in prostate cancer.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

产品性质

质量水平	200
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	DYN2-11
形式	buffered aqueous solution
分子野�/td>	antigen ~98 kDa
species reactivity	monkey, canine, rat, mouse, human
浓度	~1 mg/mL
technique(s)	immunoblotting: 2-4 ��g/mL using using whole extract of HeLa cells. immunofluorescence: 5-10 ��g/mL using using HeLa cells. immunoprecipitation (IP): 5-10 ��g using using whole extract of HeLa cells.
同位�?亚型	IgG1
UniProt登记叶�/td>	P50570
储存温度	?20ℂ�/td>
Gene Information	human ... DNM2(1785) mouse ... Dnm2(13430) rat ... Dnm2(25751)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable