产品名称９/div>
137234-62-9
Voriconazole
2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
UK-109496
伏立康唑
2R?S-2-?,4-二氟苯基?3-?-氟嘧?4-基）-1-?H-1,2,4-三唑-1-基）?2-醆br />
产品介绍９/div>
产品说明
一般描?/p>
Voriconazole is a second-generation triazole, and is derived from fluconazole. It has a broad and enhanced antifungal spectrum as compared to other older triazoles. It is mostly well tolerated and is available in both oral and intravenous formulations.
应用
Refer to the products Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-a sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.
伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖 14-甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少、br />It has been used as one of the constituent of YPD (1% yeast extract, 2% peptone, 2% glucose) liquid media.
法律信息
VETRANAL is a registered trademark of sigma-aldrich Chemie GmbH
基本信息
| 经验(实验)分子弎/td> |
C16H14F3N5O |
| 分子野/td> |
349.31 |
| MDL编号 |
MFCD00905717 |
| PubChem化学物质编号 |
329754241 |
产品性质
| 等级 |
analytical standard |
| 质量水平 |
100 |
| 产品纾/td> |
VETRANAL? |
| 保质朞/td> |
limited shelf life, expiry date on the label |
| technique(s) |
HPLC: suitable
gas chromatography (GC): suitable |
| application(s) |
forensics and toxicology
pharmaceutical (small molecule) |
| 格式 |
neat |
| SMILES string |
C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F |
| InChI |
1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
| InChI key |
BCEHBSKCWLPMDN-MGPLVRAMSA-N |
安全信息
| 象形国/td> |
  |
| 警示用语９/td> |
Danger |
| 危险声明 |
H301 - H341 - H351 - H361 - H371 - H372 - H373 - H412 |
| 预防措施声明 |
P202 - P260 - P264 - P270 - P273 - P301 + P310 |
| 危险分类 |
Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral |
| 靶器宗/td> |
Eyes |
| 储存分类代码 |
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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