产品介绍９/div>
Technical Notes:
1.Reductive Amination: Catalyst for the organocatalytic asymmetric reductive amination of aldehydes.
2.Treating racemic a-branched aldehydes with p-anisidine and a Hantzsch ester in the presence of catalyst, TRIP, gave ?-branched secondary amines.
3.a-Allylation: Highly enantioselective Pd/chiral acid-catalyzed a-allylation of a-branched aldehydes with an allyl amine as the allylating species, that creates all-carbon quaternary stereogenic centers in high yields and enantioselectivities .
3.Hydrogenation: A achiral amine in combination with a catalytic amount of a chiral Br?nsted acid can
accomplish an aldol addition-dehydration-conjugate reduction-reductive amination to provide potential intermediates of pharmaceutically active compounds in good yields and excellent enantioselectivities.
4.Friedel-Crafts Reaction: The first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Br?nsted acid.
5.Allylboration: A new high-yielding and highly enantioselective chiral Br?nsted acid-catalyzed allylboration of aldehydes .
6.Aza-Darzens Reaction: Aza-Darzens reaction of ethyl diazoacetate with aldimines, derived from phenyl glyoxal, furnished cis-aziridine carboxylates with excellent enantioselectivities by means of a chiral
phosphoric acid .
7. Intramolecular Aldol Condens ation: Transformation applicable to a wide variety of substrates to give
chiral cyclohexenones in high yields and with excellent enantioselectivity
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