Monoclonal Anti-EndoG antibody produced in mouse

Monoclonal Anti-EndoG antibody produced in mouse
Anti-Endonuclease G

产品介绍９�/div>

产品说明

一般描�?/p>

ENDOG (Endonuclease G) is a 28kDa mitochondria-localized protein mapped to human chromosome 9q34.1. However, in presence of certain conditions it can translocate to the nucleus through the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway.

免疫厞�/p>

Mouse monoclonal EndoG antibody was raised against a recombinant protein corresponding to amino acids 51 � 140 of human EndoG.

应用

Monoclonal Anti-EndoG antibody produced in mouse is suitable for indirect ELISA and western blot.

生化/生理作用

ENDOG (Endonuclease G) is a mitochondrial apoptotic DNase involved in the BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3) cell death pathway. During mitochondrial release and nuclear translocation of EndoG, BNIP3 interacts with the voltage-dependent anion channel (VDAC) to facilitate the process in the nucleus, it cleaves chromatin apoptotic DNA without the need of caspase activity. ENDOG causes DNA fragmentation during and after apoptosis. It is linked to cardiac hypertrophy and Parkinson��s disease.

特点和优劾�/p>

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied in PBS with 0.02% sodium azide.

基本信息

MDL编号	MFCD04040310
NACRES	NA.41

产品性质

质量水平	100
生物来源	mouse
偶联�?/td>	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	7G1C10, monoclonal
形式	buffered aqueous solution
species reactivity	human, rat, mouse
technique(s)	indirect ELISA: suitable western blot: suitable
NCBI登记叶�/td>	Q14249
UniProt登记叶�/td>	Q14249
运输	dry ice
储存温度	?20ℂ�/td>
Gene Information	human ... ENDOG(2021)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable