产品介绍９/div>
产品说明
一般描?/p>
Monoclonal Anti-PNK (mouse IgG1 isotype) is derived from the hybridoma H101.5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human polynucleotide kinase 3-phosphatase (PNK) recombinant protein. PNK comprises of a central phosphatase domain that is flanked by an N-terminal forkhead-associated (FHA) domain and a C-terminal kinase domain on either sides.
免疫厞/p>
human PNK recombinant protein.
应用
Monoclonal Anti-PNK antibody produced in mouse has been used in immunoblotting and immunoprecipitation.
生化/生理作用
PNK is a mammalian DNA repair enzyme which catalyzes the phosphorylation of DNA 5-hydroxyl termini and the dephosphorylation of 3-phosphate termini. PNK is involved in the single-strand break repair pathway and the non-homologous end joining pathway for double strand break repair. Mutations in PNK result in neurological abnormalities.
Polynucleotide kinase 3-phosphatase (PNKP or PNK) is a nuclear protein that repairs DNA strand breaks induced by oxidative damage or ionizing radiation. Genetic alterations in PNKP have been linked to seizures, microcephaly and deficiencies in DNA repair mechanisms .
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠、/p>
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
产品性质
| 生物来源 |
mouse |
| 偶联?/td> |
unconjugated |
| 抗体形式 |
purified from hybridoma cell culture |
| antibody product type |
primary antibodies |
| 克隆 |
H101.5, monoclonal |
| 形式 |
buffered aqueous solution |
| 分子野/td> |
antigen ~55 kDa |
| species reactivity |
human, bovine, monkey |
| 包装 |
antibody small pack of 25 L |
| 浓度 |
~1.0 mg/mL |
| technique(s) |
western blot: 2.5-5.0 g/mL using whole extracts of A549 cells |
| 同位?亚型 |
IgG1 |
| UniProt登记叶/td> |
Q96T60 |
| 运输 |
dry ice |
| 储存温度 |
?20ℂ/td> |
| Gene Information |
human ... PNKP(11284) |
安全信息
| 储存分类代码 |
12 - Non Combustible Liquids |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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