产品介绍９/div>
产品说明
一般描?/p>
Catenin beta-1 (CTNNB1) encoding -catenin, belongs to armadillo-repeat family. In human chromosome, the gene CTNNB1 is localized on 3p22.1.
免疫厞/p>
Peptide sequence around aa. 31-35 (L-D-S-G-I), according to the protein CTNNB1.
生化/生理作用
Catenin beta-1 (CTNNB1) is a signalling molecule in the nucleus and anchors actin cytoskeleton to cadherin-based adherens junctions. Phosphorylation causes dissociation of -catenin from E-cadherin and degradation by proteasome pathway. -catenin is a key molecule in wingless/integrated (wnt) signalling. -catenin forms a complex with kindlin 2 and T-cell factor 4 (TCF4) to regulate wnt target gene expression. Mutations in adenomatous polyposis coli (APC) and CTNNB1 gene affects -catenin intracellular localization and stability, contributing to aberrant expression of wnt/-catenin in malignant melanoma. -catenin is a major oncoprotein, which downregulates death associated protein kinase 2 (Dapk2) and inhibits anoikis of cancer cells. -catenin expression is suppressed and its downstream gene transcription function is regulated by a tumor suppressor protein fragile histidine triad (Fhit). High expression of mucin 1 (MUC1), translocates -catenin out of the nucleus and inhibits -catenin regulated cell proliferation. Somatic mutations of CTNNB1 in glycogen synthase kinase 3?casein kinase 1 (GSK-3?CK1) phosphorylation site results in loss of phosphorylation of -catenin. This causes aberrant wnt-signalling and leads to adrenocortical adenomas and adrenocortical carcinoma.
特点和优劾/p>
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
目标描述
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
产品性质
| 生物来源 |
rabbit |
| 质量水平 |
100 |
| 偶联?/td> |
unconjugated |
| 抗体形式 |
affinity isolated antibody |
| antibody product type |
primary antibodies |
| 克隆 |
polyclonal |
| 形式 |
buffered aqueous solution |
| 分子野/td> |
~92 kDa |
| species reactivity |
human, rat, mouse |
| 浓度 |
1 mg/mL |
| technique(s) |
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000 |
| 同位?亚型 |
IgG |
| 免疫原序刖/td> |
(L-D-S-G-I) |
| NCBI登记叶/td> |
NP_001091679.1 |
| UniProt登记叶/td> |
P35222 |
| application(s) |
research pathology |
| 运输 |
wet ice |
| 储存温度 |
?20ℂ/td> |
| Gene Information |
human ... CTNNB1(1499) |
安全信息
| 储存分类代码 |
10 - Combustible liquids |
| WGK |
WGK 1 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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