Anti-CSPG4

Anti-CSPG4
NG2
MCSPG
MCSP
HMW-MAA
MSK16

产品介绍９�/div>

产品说明

一般描�?/p>

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

免疫厞�/p>

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

生化/生理作用

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

特点和优劾�/p>

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

基本信息

NACRES

NA.41

产品性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
species reactivity	rat, human, mouse
technique(s)	immunohistochemistry: 1:20-1:100 western blot: 1:500-1:2000
登记叶�/td>	NP_001888
UniProt登记叶�/td>	Q6UVK1
运输	wet ice
储存温度	?20ℂ�/td>
Gene Information	human ... CSPG4(1464)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable