产品名称９/div>
Interleukin-12 from mouse
IL-12
产品介绍９/div>
产品说明
应用
Interleukin-12 (IL-12) from mouse has been used to study the effect of IL-12 on Th1 (type 1 T helper) immunity in Mongolian gerbils (Meriones unguiculatus) infected withSporothrix schenckii. It has been used as a standard in ELISA (enzyme-linked immunosorbent assay) cytokine assay.
生化/生理作用
Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.
外形
Lyophilized from a 0.2 m filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
基本信息
产品性质
| 质量水平 |
100 |
| 生物来源 |
mouse |
| 重组 |
expressed in baculovirus infectedSf21 cells |
| 测定 |
97% (SDS-PAGE) |
| 形式 |
lyophilized powder |
| 效能 |
0.02-0.4 ng/mL EC50 |
| 分子野/td> |
glycoprotein 70 kDa |
| 包装 |
pkg of 10 g |
| technique(s) |
cell culture | mammalian: suitable |
| 杂质 |
endotoxin, tested |
| UniProt登记叶/td> |
P43431, P43432 |
| 储存温度 |
?20ℂ/td> |
| Gene Information |
mouse ... Il12a(16159), Il12b(16160) |
安全信息
| 储存分类代码 |
13 - Non Combustible Solids |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
| 个人防护装备 |
Eyeshields, Gloves, type N95 (US) |
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