产品名称９/div>
96850-13-4
Indatraline hydrochloride
Lu 19-005
(±)-
trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride
产品介绍９/div>
产品说明
应用
Indatraline hydrochloride has been used:
- as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
- as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
- as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)
包装
10, 25, 100 mg in glass bottle
生化/生理作用
Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.
特点和优劾/p>
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
法律信息
Sold with the permission of H. Lundbeck A/S.
基本信息
| 经验(实验)分子弎/td> |
C16H15Cl2N HCl |
| 分子野/td> |
328.66 |
| MDL编号 |
MFCD00083178 |
| PubChem化学物质编号 |
24277939 |
| NACRES |
NA.77 |
产品性质
| 质量水平 |
100 |
| 形式 |
solid |
| 颜色 |
white |
| 溶解?/td> |
H2O: 2 mg/mL |
| 储存温度 |
2-8ℂ/td> |
| SMILES string |
Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 |
| InChI |
1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1 |
| InChI key |
QICQDZXGZOVTEF-MELYUZJYSA-N |
| Gene Information |
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363) |
安全信息
| 象形国/td> |
 |
| 警示用语９/td> |
Warning |
| 危险声明 |
H400 |
| 预防措施声明 |
P273 |
| 危险分类 |
Aquatic Acute 1 |
| 储存分类代码 |
13 - Non Combustible Solids |
| WGK |
WGK 3 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
| 个人防护装备 |
Gloves |
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