产品介绍９/div>
产品说明
一般描?/p>
The human VEGFA, a 45 kDa homodimeric glycoprotein, is one of the most potent angiogenic factors involved in endothelial cell proliferation, migration, and secretion of MMPs. It also serves as an important survival factor for endothelial cells, inhibiting apoptosis. VEGFA belongs to a family that includes VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor (PLGF). In humans four prominent isoforms of VEGFA are recognized, VEGF121, VEGF165, VEGF189, and VEGF206. In addition, two other less frequent splice variants, VEGF145 and VEGF183, have also been reported. The properties of native VEGF are very similar to VEGF165. Of all the different isoforms of VEGF, the VEGF165 has the highest bioavailability and biological potency. VEGFA action is mediated by VEGF receptor-1 (VEGFR-1) and VEGFR-2. VEGFR-1 (180 kDa, Flt-1) expression is upregulated by hypoxic conditions in the inner core of tumor mass. VEGFR-2 (200 kDa, KDR) is a major mediator of mitogenic and angiogenic permeability enhancing effects of VEGF. It is also reported to mediate survival signals in endothelial cells.
免疫厞/p>
Epitope: Near N-terminus
KLH-conjugated linear peptide corresponding to mouse VEGF-A near the N-terminus.
应用
Research Sub Category
Metabolic Hormones & Receptors
Anti-VEGF-A Antibody is an antibody against VEGF-A for use in Western Blotting and Immunohistochemistry (Paraffin).
Research Category
Signaling
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected VEGF-A in mouse kidney, mouse cerebellum, mouse spleen, and rat kidney tissue.
质量
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 2.0 ?g/mL of this antibody detected VEGF-A in 10 ?g of mouse lung tissue lysate.
目标描述
~27 kDa observed
联系
Replaces: AB1876
外形
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity
储存及稳定?/p>
Stable for 1 year at 2-8C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss |
32160702 |
| NACRES |
NA.41 |
产品性质
| 生物来源 |
rabbit |
| 质量水平 |
100 |
| 抗体形式 |
affinity isolated antibody |
| antibody product type |
primary antibodies |
| 克隆 |
polyclonal |
| 纯化方式 |
affinity chromatography |
| species reactivity |
rat, mouse |
| technique(s) |
immunohistochemistry: suitable (paraffin)
western blot: suitable |
| NCBI登记叶/td> |
NP_001273985 |
| UniProt登记叶/td> |
Q00731 |
| 运输 |
wet ice |
安全信息
| 储存分类代码 |
12 - Non Combustible Liquids |
| WGK |
WGK 1 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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