产品介绍９/div>
产品说明
一般描?/p>
Mu Opioid Receptor (MOP), also called Mu-type opioid receptor (MOR-1), is a receptor for natural and synthetic opioids such as beta-endorphin, endomorphin, morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. MOP functions as a class A G-protein coupled receptor (GPCR), but its down-regulation pathways vary with the agonist and may or may not be independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling, as opposed to synthetic ligands, like morphine, that trigger only low desensitization and endocytosis. Hetero-oligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. MOP is expressed in the brain and is involved in neurogenesis. MOP is the main physiological target for most clinically important opioid analgesics.
特异?/p>
This antibody recognizes the C-terminus of Mu Opioid Receptor. This antibody will recognize isoform 1 (45 kDa), isform 10 (55 kDa), isoform 12 (34 kDa), and isoform 13 (36 kDa).
免疫厞/p>
KLH-conjugated linear peptide corresponding to the C-terminus of human Mu Opioid Receptor.
应用
Detect Opioid Receptor using this rabbit polyclonal antibody, Anti-Mu Opioid Receptor Antibody validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:1,000-4,000 dilution from a representative lot detected Mu Opioid Receptor in human cerebellum, mouse hippocampus, mouse midbrain, and rat midbrain tissue.
质量
Evaluated by Western Blotting in SH-SY5Y cell lysate.
Western Blotting Analysis: 0.2 ?g/mL of this antibody detected Mu Opioid Receptor in 10 ?g of SH-SY5Y cell lysate.
目标描述
~70 kDa observed. The calculated molecular weight is 45 kDa, however Opioid Receptor mu has been shown as a ~70-90 kDa band in western blots (Ferrer-Alcon, M., et al. (2004). Molecular Brain Research. 121(1-2):114-122).
联系
Replaces: AB1580
外形
Affinity purified
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss |
32160702 |
| NACRES |
NA.41 |
产品性质
| 生物来源 |
rabbit |
| 质量水平 |
100 |
| 抗体形式 |
affinity isolated antibody |
| antibody product type |
primary antibodies |
| 克隆 |
polyclonal |
| 纯化方式 |
affinity chromatography |
| species reactivity |
human, mouse |
| species reactivity (predicted by homology) |
porcine (based on 100% sequence homology), rat (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) |
immunohistochemistry: suitable (paraffin)
western blot: suitable |
| NCBI登记叶/td> |
NP_000905 |
| UniProt登记叶/td> |
P35372 |
| 运输 |
wet ice |
| Gene Information |
human ... OPRM1(4988) |
安全信息
| 储存分类代码 |
12 - Non Combustible Liquids |
| WGK |
WGK 1 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
m.cnreagent.com
