Heregulin-β, EGF Domain human

Heregulin-β, EGF Domain human
HRG-β

产品介绍９�/div>

产品说明

一般描�?/p>

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

生化/生理作用

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

外形

Solution in phosphate buffered saline containing 30% glycerol.

分析说明

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

基本信息

MDL编号	MFCD01867052
NACRES	NA.32

产品性质

质量水平	200
生物来源	human
重组	expressed inE. coli
测定	��80% (SDS-PAGE)
形式	buffered aqueous glycerol solution
分子野�/td>	185 kDa
包装	pkg of 100 ��g
储存条件	avoid repeated freeze/thaw cycles
UniProt登记叶�/td>	Q02297
运输	dry ice
储存温度	?20ℂ�/td>
Gene Information	human ... NRG1(3084)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable