产品介绍９/div>
产品说明
一般描?/p>
PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported in vitro with transformation of cell cultures and in vivo with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).3
质量
联系
PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
产品性质
| 生物来源 |
rabbit |
| 质量水平 |
500
100 |
| 偶联?/td> |
unconjugated |
| 抗体形式 |
culture supernatant |
| antibody product type |
primary antibodies |
| 克隆 |
EP235, monoclonal |
| 描述 |
(For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 形式 |
buffered aqueous solution |
| species reactivity |
human |
| 包装 |
bottle of 1.0 mL predilute (311R-17)
bottle of 7.0 mL predilute (311R-18)
vial of 0.1 mL concentrate (311R-14)
vial of 0.5 mL concentrate (311R-15)
vial of 1.0 mL concentrate (311R-16) |
| manufacturer/tradename |
Cell Marque? |
| technique(s) |
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50 |
| 同位?亚型 |
IgG |
| 运输 |
wet ice |
| 储存温度 |
2-8ℂ/td> |
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