产品介绍９/div>
产品说明
一般描?/p>
Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing, although it seems that the level of its expression can be used as a marker of B-cell lineage and differentiation. The following show high levels of Oct-2 expression: germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, classic Hodgkin lymphoma.
Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines display high levels of expression. Analysis of Oct-2 expression in primary Hodgkin′s lymphoma (HLs) and cell lines derived from it showed that the tumor cells analyzed had high levels of expression and activity, suggesting a common B-cell origin for all types of HLs.
Associated products: bcl-6, CD20, CD79a, PAX-5, BOB.1
质量
联系
Oct-2 Positive Control Slides, Product No. 308S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
产品性质
| 质量水平 |
500
100 |
| 生物来源 |
mouse |
| 偶联?/td> |
unconjugated |
| 抗体形式 |
diluted ascites fluid |
| antibody product type |
primary antibodies |
| 克隆 |
MRQ-2, monoclonal |
| 描述 |
For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 形式 |
buffered aqueous solution |
| species reactivity |
human |
| 包装 |
vial of 0.1 mL concentrate (308M-14)
vial of 0.5 mL concentrate (308M-15)
bottle of 1.0 mL predilute (308M-17)
vial of 1.0 mL concentrate (308M-16)
bottle of 7.0 mL predilute (308M-18) |
| manufacturer/tradename |
Cell Marque? |
| technique(s) |
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| 同位?亚型 |
IgG1 |
| 控制 |
tonsil |
| 运输 |
wet ice |
| 储存温度 |
2-8ℂ/td> |
| 可视匕/td> |
nuclear |
安全信息
| 储存分类代码 |
12 - Non Combustible Liquids |
| WGK |
WGK 2 |
| 闪点(F) |
Not applicable |
| 闪点(C) |
Not applicable |
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