产品介绍９/div>
产品说明
一般描?/p>
Rhabdomyosarcomas (RMS) are the most frequent malignant soft tissue neoplasms of childhood. While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors. MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers. Normal mature skeletal muscle does not express MyoD1 protein. MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated RMS. Studies suggest, anti-MyoD1 may be used together with anti-myogenin and anti-desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.
质量
联系
MyoD1 Positive Control Slides, Product No. 386S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
产品性质
| 生物来源 |
rabbit |
| 质量水平 |
500
100 |
| 偶联?/td> |
unconjugated |
| 抗体形式 |
culture supernatant |
| antibody product type |
primary antibodies |
| 克隆 |
EP212, monoclonal |
| 描述 |
For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 形式 |
buffered aqueous solution |
| species reactivity |
human |
| 包装 |
vial of 0.1 mL concentrate (386R-14)
vial of 0.5 mL concentrate (386R-15)
bottle of 1.0 mL predilute (386R-17)
vial of 1.0 mL concentrate (386R-16)
bottle of 7.0 mL predilute (386R-18) |
| manufacturer/tradename |
Cell Marque? |
| technique(s) |
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| 同位?亚型 |
IgG |
| 控制 |
rhabdomyosarcoma |
| 运输 |
wet ice |
| 储存温度 |
2-8ℂ/td> |
| 可视匕/td> |
nuclear |
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