| In Vitro |
EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. |
| In Vivo |
EVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. |
| Animal model |
male SD rats with carrageenin induced paw edema |
| Formulation & Dosage |
0.5% hydroxypropyl cellulose; 1 mg/kg; i.p injection |
| References |
[1] Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391. |
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