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Thalidomide(Immunoprin,Contergan and Thalomid)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、/div>
Thalidomide(Immunoprin,Contergan and Thalomid)图片
CAS NO: 50-35-1
规格: ?8%
包装与价格：
包装 价格(?
100mg 电议
500mg 电议
1g 电议
2g 电议
5g 电议
10g 电议

产品介绍
理化性质和储存条仵/div>
Molecular Weight (MW) 258.23
Formula C13H10N2O4
CAS No. 50-35-1
Storage -20 for 3 years in powder form
-80 for 2 years in solvent
Solubility(In vitro) DMSO: 52 mg/mL (201.37 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 2 mg/mL (7.74 mM)
Solubility(In vivo) 30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL
Chemical Name

Chemical Name: 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChi Key: UEJJHQNACJXSKW-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

SMILES Code: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
Synonyms Brand names: Synovir; Thalomid (US); Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide.
实验参考方泔/div>
In Vitro Thalidomide must be metabolized by the liver to form an epoxide that may be the active teratogenic metabolite. Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when human monocytes are triggered with lipopolysaccharide and other agonists in culture.
In Vivo Thalidomide (100 mg/kg, p.o.) inhibits the collagen deposition, down-regulates the mRNA expression level of α-SMA and collagen I, and significantly reduces the pro-inflammatory cytokines in RILF mice. Thalidomide alleviates RILF via suppression of ROS and down-regulation of TGF-β/Smad pathway dependent on Nrf2 status. Thalidomide (200 mg/kg, p.o.) combined with icotinib shows synergistic anti-tumor effects in nude mice bearing PC9 cells, suppressing tumor growth and promoting tumor death.
Animal model C57BL/6 mice
Formulation & Dosage 100 mg/kg, p.o.
References [1] D Amato RJ, et al. Proc Natl Acad Sci U S A, 1994, 91(9), 4082-4085. ; Free Radic Biol Med. 2018 Dec;129:446-453.
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