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Pomalidomide(CC4047 or actimid)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、/div>
Pomalidomide(CC4047 or actimid)图片
CAS NO: 19171-19-8
规格: ?8%
包装与价格：
包装 价格(?
50mg 电议
100mg 电议
250mg 电议
500mg 电议
1g 电议
2g 电议

产品介绍
理化性质和储存条仵/div>
Molecular Weight (MW) 273.24
Formula C13H11N3O4
CAS No. 19171-19-8
Storage -20 for 3 years in powder form
-80 for 2 years in solvent
Solubility(In vitro) DMSO: 55 mg/mL (201.28 mM) )
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
Solubility(In vivo) 1% DMSO+30% polyethylene glycol+1% Tween 80: 15 mg/mL
Chemical Name/Synonyms 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; CC4047; CC 4047; CC-4047; Brand name: Pomalyst.
实验参考方泔/div>
In Vitro Pomalidomide at 1 μM increased HbF production in human erythroid cells. After 6 days, Pomalidomide at 1 μM induced γ-globin mRNA levels upregulation 2-fold while decreased β-globin levels 2-fold.
In Vivo Pomalidomide enhances the antitumor effect of rituximab against B-cell lymphomas in severe combined immunodeficient mice.
Animal model Disseminated lymphoma-bearing SCID mice
Formulation & Dosage Dissolved in DMSO to make a 10 mg/mL stock solution and diluted to a final concentration of 1 mg/mL in sterile 0.9% normal saline. 0.5 mg/kg; i.p.
References [1] Hernandez-Ilizaliturri FJ, et al. Clin Cancer Res, 2005, 11(16), 5984-5992.
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