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Q-VD-OPH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、/div>
Q-VD-OPH图片
CAS NO: 1135695-98-5
规格: ?8%
包装与价格：
包装 价格(?
2mg 电议
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议
250mg 电议
500mg 电议

产品介绍
理化性质和储存条仵/div>
Molecular Weight (MW) 513.49
Formula C26H25F2N3O6
CAS No. 1135695-98-5
Storage -20 for 3 years in powder form
-80 for 2 years in solvent
Solubility(In vitro) DMSO: 100 mg/mL (194.74 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 100 mg/mL (194.74 mM)
Synonyms QVD-OPH; Q-VD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone. quinoline-val-asp(OMe)-CH2-OPH.
Other info

Chemical Name: (3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid

InChi Key: OOBJCYKITXPCNS-REWPJTCUSA-N

InChi Code: InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1

SMILES Code: O=C(O)C[C@H](NC([C@@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O
实验参考方泔/div>
In Vitro Q-VD-OPh (5-100 μM) potently inhibits Actinomycin D-induced DNA laddering and subsequent apoptosis with minimal toxicity in WEHI 231 cells. Q-VD-OPh prevents caspase mediated cleavage of PARP and activation of the major initiator and effector caspases. Q-VD-OPh protects cardiac myocytes from virus-induced apoptosis in vitro
In Vivo Q-VD-OPh inhibited caspase-7 activation and limited the pathological changes of tau and caspase cleavage in chronic treatment of Alzheimer disease.
Animal model TgCRND8 mice in 3 months-old
Formulation & Dosage Intraperitoneally Injected with 10 mg/kg QVD-OPh at 3 times a week for 3 months
References J Cell Biochem. 2011 Nov;112(11):3334-42; Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.
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