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Z-DEVD-FMK
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、/div>
Z-DEVD-FMK图片
CAS NO: 210344-95-9
规格: ?8%
包装与价格：
包装 价格(?
2mg 电议
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议
250mg 电议

产品介绍
理化性质和储存条仵/div>
Molecular Weight (MW) 668.66
Formula C30H41FN4O12
CAS No. 210344-95-9
Storage -20 for 3 years in powder form
-80 for 2 years in solvent
Solubility(In vitro) DMSO: 100 mg/mL (149.55 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
Other info

Chemical Name: methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

InChi Key: GBJVAVGBSGRRKN-JYEBCORGSA-N

InChi Code: InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1

SMILES Code: O=C(OC)CC[C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(OC)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O
Synonyms L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester; Z-DEVD-fmk; Z DEVD fmk; ZDEVDfmk
实验参考方泔/div>
In Vitro Z-DEVD-FMK (1?00 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner. Z-DEVD-FMK reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Z-DEVD-FMK (100 μM) blocks MPP+-induced increases in caspase-3 enzyme activity. Z-DEVD-FMK dose dependently blocks 6-OHDA-induced apoptotic cell death with IC50 of 18 μM.
In Vivo Z-DEVD-FMK, before and after injury, markedly reduces post-traumatic apoptosis, and significantly improved neurological recovery
Animal model Male Sprague Dawley rats with Brain trauma.
Formulation & Dosage DMSO; 160 ng; Intracerebroventricular administration
References [1] Rickers A, et al. Eur J Immunol. 1998, (1), 296-304.; [2] Yakovlev AG, et al. J Neurosci. 1997, 17(19), 7415-7424.
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