[ 登录] [ 免费注册]
试剂仪器? title=
发布求购
位置９a href="/">首页> 产品庒/a> > Belnacasan(VX765)
立即咨询
咨询类型９/div>
*姓名９/div>
*电话９/div>
*单位９/div>
Email９/div>
*留言内容９/div>
请详细说明您的需求
*验证码：
Belnacasan(VX765)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、/div>
Belnacasan(VX765)图片
CAS NO: 273404-37-8
规格: ?8%
包装与价格：
包装 价格(?
2mg 电议
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议
250mg 电议

产品介绍
理化性质和储存条仵/div>
Molecular Weight (MW) 508.99
Formula C24H33ClN4O6
CAS No. 273404-37-8
Storage -20 for 3 years in powder form
-80 for 2 years in solvent
Solubility(In vitro) DMSO: 100 mg/mL warming (196.46 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 100 mg/mL warming (196.46 mM)
Other info Solubility (In vivo): 2% DMSO+30% PEG 300+ddH2O: 5 mg/mL
Synonym: VX 765, VX765, VX-765, Belnacasan

Chemical Name: (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide

SMILES Code: O=C([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)N[C@@H](C3)[C@H](OCC)OC3=O
实验参考方泔/div>
General In a CIA mouse model, VX-765 significantly reduced the inflammation scores in a dose-dependent manner. In addition, 100 mg/kg VX-765 was as efficacious as 5 mg/kg Prednisolone.
Animal model Collagen-induced arthritis (CIA) mouse model
Formulation VX-765 is dissolved in 25% Cremophor EL
Dosages 10, 25, 50 or 100 mg/kg
Administration p.o.; b.i.d.; for 24 days.
References [1] Wannamaker W, et al. J Pharmacol Exp Ther. 2007, 321(2), 509-516.
生物活?/div>

Dose response of VX-765 in LPS-induced IL-1β production in vivo. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.
Effects of VX-765 on ear swelling induced by oxazolone.J Pharmacol Exp Ther. 2007 May;321(2):509-16.

Effects of VX-765 on production of inflammatory mediators in biopsy samples from oxazolone-challenged mouse ears (n = 6/group). J Pharmacol Exp Ther. 2007 May;321(2):509-16.

Effects of VX-765 on forepaw inflammation in the mouse CIA model administered in either the prophylactic (A) or therapeutic (B) regimen. J Pharmacol Exp Ther. 2007 May;321(2):509-16.


Baidu
map