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Tenovin-6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、�/div>

CAS NO:	1011557-82-6
规格:	�?8%

包装与价格：

产品介绍

理化性质和储存条仵�/div>

Molecular Weight (MW)	454.63
Formula	C25H34N4O2S
CAS No.	1011557-82-6
Storage	-20� for 3 years in powder form
Storage	-80� for 2 years in solvent
Solubility(In vitro)	DMSO: 98 mg/mL (215.55 mM)
	Water:<1 mg/mL (slightly soluble or insoluble)
	Ethanol: <1 mg/mL (slightly soluble or insoluble)
Solubility(In vivo)	Tenovin-6; Tenovin 6; Tenovin6

实验参考方泔�/div>

General	Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively.
Animal model	ARN8 melanoma cells were injected into the flank of SCID mice and allowed to develop into tumors.
Formulation
Dosages	50 mg/kg
Administration	i.p.
References	[1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

生物活�?/div>

Tenovin-6 Delays Tumor Growth In Vivo. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Tenovin-6 Inhibits the Protein Deacetylase Activities of Purified Sirtuins SirT1 and SirT2