Pifithrin-α(PFTα) - �뵺�羺�ٷ��ַ

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Pifithrin-α(PFTα)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验、�/div>

CAS NO:	63208-82-2
规格:	�?8%

包装与价格：

包装	价格(�?
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
250mg	电议
500mg	电议

产品介绍

理化性质和储存条仵�/div>

Molecular Weight (MW)	367.3
Formula	C16H18N2OS.HBr
CAS No.	63208-82-2
Storage	-20� for 3 years in powder form
Storage	-80� for 2 years in solvent
Solubility(In vitro)	DMSO: 67 mg/mL (182.41 mM)
	Water:<1 mg/mL (slightly soluble or insoluble)
	Ethanol: 2 mg/mL (6.08 mM)
Solubility(In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SMILES Code	CC1=CC=C(C(CN2C(SC3=C2CCCC3)=N)=O)C=C1.[H]Br
Synonyms	Pifithrin-alpha; Pifithrin alpha; PFTalpha; PFTalpha; PFT alpha

实验参考方泔�/div>

General	Pifithrin-α (2.2 mg/kg i.p.) treatment completely rescues mice (C57BL and Balb/c) of both strains from 60% killing doses of gamma irradiation (8 Gy for C57BL and 6 Gy for Balb/c). Pifithrin-α-injected mice lost less weight than irradiated mice that are not pretreated with the Pifithrin-α. Pifithrin-α (2.2 mg/kg) abrogates p53-dependent regulation of DNA replication after whole-body gamma irradiation in mice.
Animal model	C57BL and Balb/c mice
Formulation	Dissolved in Saline
Dosages	2.2 mg/kg
Administration	i.p
References	[1] Komarov PG, et al. Science, 1999, 285(5434), 1733-1737.

生物活�?/div>

IS upregulates α-SMA protein through p53 and ROS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.

IS induces activated p53 expression, which is involved in suppression of serum-induced proliferation of HK-2 cells caused by IS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.

IS-induced HK-2 cell senescence is inhibited by PFTα. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.