基因名：

BTLA

产品别名９�p style="text-indent: 2em;">BTLA1� CD272� BTLA� B and T lymphocyte associated� B and T lymphocyte associated� B- and T-lymphocyte attenuator� B- and T-lymphocyte-associated protein� B/T-淋巴细胞衰减因子(BTLA)� B和T淋巴细胞衰减蛋白�

背景信息９�div style="text-indent: 2em;">B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.