PF-3644022 (PF3644022) is a novel, potent, selective, orally bioactive, and ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) with anticancer activity. It inhibits MAPK2-MK2 with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM).

纯度：≥98%

CAS�?276121-88-0