生物活?/h4>
23-Hydroxybetulinic acid is a novel anticancer substance. 23-Hydroxybetulinic acid enhanced the cytotoxicity of ABCB1 substrates and increased the accumulation of doxorubicin or rhodamine123 in ABCB1 overexpressing cells, but had no effect on non ABCB1 substrate, such as cisplatin. In addition, 23-Hydroxybetulinic acid inhibited the verapamil-stimulated ABCB1 ATPase activity and the photolabeling of ABCB1 with [(125)I] iodoarylazidoprazosin in a concentration-dependent manner, indicating that 23-Hydroxybetulinic acid directly interacts with ABCB1. Importantly, 23-Hydroxybetulinic acid increased the inhibitory effect of paclitaxel in ABCB1 overexpressing KB-C2 cell xenografts in nude mice.
化学数据
| 分子野/td> |
472.7 |
| 分子弎/td> |
C30H48O4 |
| CAS叶/td> |
85999-40-2 |
| 纯度 |
>98% |
| 溶解性（25C（/td> |
DMSO |
| 储存和运输条仵/td> |
固体粉末 -20C 冷藏长期储存
常温运输及临时存攽/td> |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南（/h4>
|
小鼠 |
大鼠 |
兓/td> |
豚鼠 |
仓鼠 |
狖/td> |
| 重量 (kg) |
0.02 |
0.15 |
1.8 |
0.4 |
0.08 |
10 |
| 体表面积 (m2) |
0.007 |
0.025 |
0.15 |
0.05 |
0.02 |
0.5 |
| Km系数 |
3 |
6 |
12 |
8 |
5 |
20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × |
动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数?），再除以大鼠的Km系数?），得到化合物用于大鼠的等效剂量?0 mg/kg、/p>
储备液配刵/h4>
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作、/p>
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
2.1155 mL |
10.5775 mL |
21.1551 mL |
| 5 mM |
0.4231 mL |
2.1155 mL |
4.231 mL |
| 10 mM |
0.2116 mL |
1.0578 mL |
2.1155 mL |
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