JVW-1009 is a selective modulator of sigma 2 receptor which acts neuroprotective in a C. elegans model of amyloid precursor protein-mediated neurodegeneration. References: Yi B, Sahn JJ, Ardestani PM, Evans AK, Scott LL, Chan JZ, Iyer S, Crisp A, Zuniga G, Pierce JT, Martin SF, Shamloo M. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. J Neurochem. 2017 Feb;140(4):561-575. doi: 10.1111/jnc.13917. PubMed PMID: 27926996; PubMed Central PMCID: PMC5312682.

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