Biotin, formerly known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). It is composed of a ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. References: Coffey CM, Gronert S. A cleavable biotin tagging reagent that enables the enrichment and identification of carbonylation sites in proteins. Anal Bioanal Chem. 2015 Nov 27. [Epub ahead of print] PubMed PMID: 26613796.

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CAS�?8-85-5