生物活?/h4>
SAG是一种含氯苯并噻吩的化合物，可作为SMO激动剂（EC50 = 3 nM），但在高浓度（> 1 uM）下抑制刺猬信号
化学数据
| 目录叶/td> |
A13627 |
| 作用机制 |
Agonist (激动剂) |
| M. Wt |
490.1 |
| Formula |
C28H28ClN3OS |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
912545-86-9 |
| Synonyms |
Smoothened Agonist |
| SMILES |
CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl |
储备液配刵/h4>
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
20.4 mL |
102.02 mL |
204.04 mL |
| 0.5 mM |
4.08 mL |
20.4 mL |
40.81 mL |
| 1 mM |
2.04 mL |
10.2 mL |
20.4 mL |
| 5 mM |
0.41 mL |
2.04 mL |
4.08 mL |
*The above data is based on the productmolecular weight 490.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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