生物活?/h4>
Brexpiprazole是一种新型的D2多巴胺部分激动剂研究产品，目前正在临床试验中，用于治疗抑郁症，精神分裂症和注意缺陷多动障碍（ADHD）
靶点信息
| 5-HT1A |
human noradrenergic 1B |
Dopamine D2L |
5-HT2A receptors |
2C receptors |
| 0.12 nM(Ki) |
0.17 nM(Ki) |
0.3 nM(Ki) |
0.47 nM(Ki) |
0.59 nM(Ki) |
化学数据
| 目录叶/td> |
A13527 |
| 作用机制 |
Agonist (激动剂) |
| M. Wt |
433.5733 |
| Formula |
C25H27N3O2S |
| Purity |
>99% |
| Storage |
Store lyophilized at -20?C, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. |
913611-97-9 |
| Synonyms |
OPC 34712, OPC-34712 |
| SMILES |
C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4 |
溶解?/h4>
| In vitro |
DMSO |
21 mg/mL (48.43 mM) |
| Water |
Insoluble |
| Ethanol |
Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配刵/h4>
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 0.1 mM |
23.06 mL |
115.32 mL |
230.64 mL |
| 0.5 mM |
4.61 mL |
23.06 mL |
46.13 mL |
| 1 mM |
2.31 mL |
11.53 mL |
23.06 mL |
| 5 mM |
0.46 mL |
2.31 mL |
4.61 mL |
*The above data is based on the productmolecular weight 433.5733. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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