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K-Ras ligand-Linker Conjugate 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验、/div>
包装: 50mg, 100mg, 250mg
规格: ?8%

产品介绍

K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is highly potent PROTAC K-Ras degrader that exhibits ?0% degradation efficacy in SW1573 cells. References: [1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

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