Enmein 仍i>I. serra中分离，具有免疫抑制作用、/div>
| 生物活?/td> |
Enmein is isolated fromI. serrawith immunosuppressive effect[1].
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体外研究
(In Vitro) |
Enmein shows significant inhibitory effect toward K562 with an IC50value ranging from 3.2 μg/ml to 8.2 μg/ml[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%[1].
Cell Viability Assay[1]
| Cell Line: |
Splenic lymphocyte cells |
| Concentration: |
3.13, 6.25, 12.5, 25 μg/ml |
| Incubation Time: |
48 hours |
| Result: |
Exhibited an IC50value of 17 μg/ml in splenic lymphocytes. |
Cell Cycle Analysis[1]
| Cell Line: |
Splenic lymphocyte cells |
| Concentration: |
5.5 μg/ml, 11 μg/ml, 22 μg/ml |
| Incubation Time: |
48 hours |
| Result: |
Caused S stage cells and G2/M stage cells decreased. |
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体内研究
(In Vivo) |
Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1].
| Animal Model: |
Balb/c mice[1] |
| Dosage: |
6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg |
| Administration: |
Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days |
| Result: |
Had inhibitory effect on IL-2 release in blood. |
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| 分子野/td> |
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| Formula |
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| CAS 叶/td> |
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| 结构分类 |
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| 来源 |
- Plants
- Labiatae
- Rabdosia serra(Maxim.) Hara
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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