Dencichin is a non-protein amino acid originally extracted fromPanax notoginseng, and can inhibitHIF-prolyl hydroxylase-2 (PHD-2)activity.

PHD-2^[1]

Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2^[1]. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN)^[2].

Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models^[2].

176.13

Solid

C₅H₈N₂O₅

5302-45-4

三七紟�/p>

• Amino acids

• Plants
• Araliaceae
• Panax notoginseng

Room temperature in continental US; may vary elsewhere.

4��C, protect from light

*In solvent : -80��C, 6 months; -20��C, 1 month (protect from light)

H₂O : 5 mg/mL(28.39 mM;Need ultrasonic)

DMSO : 5 mg/mL(28.39 mM;Need ultrasonic)