Angoline hydrochloride 是一种有效的、选择性的
IL6/STAT3信号通路抑制剂，
IC50 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖、/div>
| 生物活?/td> |
Angoline hydrochloride is a potent and selectiveIL6/STAT3 signaling pathwayinhibitor with anIC50of 11.56 μM. Angoline hydrochloride inhibitsSTAT3phosphorylation and its target gene expression, and inhibitscancercell proliferation[1].
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| IC50& Target |
IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)[1]
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体外研究
(In Vitro) |
Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50values of 11.56, ?00 and ?00 μM, respectively[1].
Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3[1].
Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1].
Western Blot Analysis[1]
| Cell Line: |
HepG2/STAT3 cell lines |
| Concentration: |
0, 1, 10, 30 and 100 μM |
| Incubation Time: |
2 hours |
| Result: |
Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells. |
Western Blot Analysis[1]
| Cell Line: |
MDA-MB-231, H4 and HepG2 cell lines |
| Concentration: |
0-100 μM |
| Incubation Time: |
72 hours |
| Result: |
Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50values of 3.32, 4.72 and 3.14 μM, respectively. |
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| 分子野/td> |
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| Formula |
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| CAS 叶/td> |
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| 结构分类 |
- Alkaloids
- Isoquinoline Alkaloids
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| 来源 |
- Plants
- Papaveraceae
- Macleaya cordata(Willd.) R. Br.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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