靶标９�p style="text-indent: 2em;">TAF6

产品别名９�p style="text-indent: 2em;">ALYUS� MGC:8964� TAF(II)70� TAF(II)80� TAF2E� TAFII-70� TAFII-80� TAFII70� TAFII80� TAFII85� TAF6� TATA-box binding protein associated factor 6� TATA-box binding protein associated factor 6� transcription initiation factor TFIID subunit 6� RNA polymerase II TBP-associated factor subunit E� TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa� TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD� transcription initiation factor TFIID 70 kDa subunit� 转录起始因子TFIID亚基6�

背景信息９�div style="text-indent: 2em;">Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants.