靶标９�p style="text-indent: 2em;">SLC11A1

产品别名９�p style="text-indent: 2em;">LSH� NRAMP� NRAMP1� SLC11A1� solute carrier family 11 member 1� solute carrier family 11 member 1� natural resistance-associated macrophage protein 1� NRAMP 1� solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1� solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1� solute carrier family 11 (sodium/phosphate symporters), member 1� 自然抗性相关巨噬细胞蛋�?�

背景信息９�div style="text-indent: 2em;">Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1gene. It is mapped to 2q35. This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.