靶标９�p style="text-indent: 2em;">MS4A2

产品别名９�p style="text-indent: 2em;">APY� ATOPY� FCER1B� FCERI� IGEL� IGER� IGHER� MS4A2� membrane spanning 4-domains A2� membrane spanning 4-domains A2� high affinity immunoglobulin epsilon receptor subunit beta� Fc fragment of IgE, high affinity I, receptor for; beta polypeptide� High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)� high affinity IgE receptor beta subunit� igE Fc receptor subunit beta� immunoglobulin E receptor, high affinity, beta polypeptide� membrane-spanning 4-domains subfamily A member 2� 跨膜结构�?亚家族成�?�

背景信息９�div style="text-indent: 2em;">The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.