靶标９�p style="text-indent: 2em;">FGD1

产品别名９�p style="text-indent: 2em;">AAS� FGDY� MRXS16� ZFYVE3� FGD1� FYVE, RhoGEF and PH domain containing 1� FYVE, RhoGEF and PH domain containing 1� FYVE, RhoGEF and PH domain-containing protein 1� faciogenital dysplasia 1 protein� rho/Rac GEF� rho/Rac guanine nucleotide exchange factor FGD1� zinc finger FYVE domain-containing protein 3� FGD1蛋白�

背景信息９�div style="text-indent: 2em;">This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011],