靶标９�p style="text-indent: 2em;">ATP6V0C

产品别名９�p style="text-indent: 2em;">ATP6C� ATP6L� ATPL� VATL� VPPC� Vma3� ATP6V0C� ATPase H+ transporting V0 subunit c� ATPase H+ transporting V0 subunit c� V-type proton ATPase 16 kDa proteolipid subunit c� ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c� H(+)-transporting two-sector ATPase, 16 kDa subunit� V-ATPase 16 kDa proteolipid subunit� V-ATPase 16 kDa proteolipid subunit c� V-type proton ATPase 16 kDa proteolipid subunit� vacuolar ATP synthase 16 kDa proteolipid subunit� vacuolar H+ ATPase proton channel subunit� vacuolar proton pump 16 kDa proteolipid subunit� vacuolar proton pump 16 kDa proteolipid subunit c�

背景信息９�div style="text-indent: 2em;">This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.