靶标９�p style="text-indent: 2em;">ATP6V0A1

产品别名９�p style="text-indent: 2em;">ATP6N1� ATP6N1A� Stv1� VPP1� Vph1� a1� ATP6V0A1� ATPase H+ transporting V0 subunit a1� ATPase H+ transporting V0 subunit a1� V-type proton ATPase 116 kDa subunit a 1� ATPase, H+ transporting, lysosomal V0 subunit a1� ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)� H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1� V-ATPase 116 kDa subunit a 1� V-ATPase 116 kDa subunit a1� V-ATPase subunit a1� V-type proton ATPase 116 kDa subunit a� V-type proton ATPase 116 kDa subunit a1� clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit� vacuolar adenosine triphosphatase subunit Ac116� vacuolar proton pump subunit 1� vacuolar proton translocating ATPase 116 kDa subunit A� vacuolar-type H(+)-ATPase 115 kDa subunit� 氢离子转运ATP合成酶A1�

背景信息９�div style="text-indent: 2em;">This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.