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位置: 首页> 品牌> Sigma-Aldrich> PAX-8 Rabbit Polyclonal Antibody

PAX-8 Rabbit Polyclonal Antibody

品牌
Sigma-Aldrich
货号
363A-1
包装型号
规格纯度
价格
3531.56 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
PAX-8 Rabbit Polyclonal Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This protein is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 experession in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Most recently a study by Tong et al. showed that 98% of clear cell RCCs, 90% of papillary RCCs, and 95% of oncocytomas were positive for PAX-8, frequencies which are similar or better than for PAX-2. Therefore, PAX-8 may be used as an additional immunohistochemical marker for renal epithelial tumors. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities. PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary, bladder, lung, or breast.

质量


IVD

IVD

IVD

RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 500
100
偶联物 unconjugated
抗体形式 Ig fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
描述 For In Vitro Diagnostic Use in Select Regions (See Chart)
形式 buffered aqueous solution
species reactivity human
包装 vial of 0.1 mL concentrate (363A-14)
vial of 0.5 mL concentrate (363A-15)
bottle of 1.0 mL predilute (363A-17)
bottle of 7.0 mL predilute (363A-18)
manufacturer/tradename Cell Marque?
technique(s) immunohistochemistry: 1:25-1:100
运输 wet ice
储存温度 2-8℃

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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