WEE1-IN-5 - 半岛电竞官方网址

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WEE1-IN-5

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2243882-74-6

包装与价格：

半岛bd体育手机客户端介绍

WEE1-IN-5 是一种有效的 WEE1 抑制剂，IC50 为 0.8 nM。WEE1-IN-5 可抑制磷酸化 CDC2。WEE1-IN-5 消除 G2 检查点，增加癌细胞对 DNA 损伤剂 Carboplatin 的敏感性。WEE1-IN-5 可用于抗癌研究。$

Cas No.	2243882-74-6
分子式	C₂₆H₂₈Cl₂N₆O
分子量	511.45
溶解度	DMSO : 125 mg/mL (244.40 mM; Need ultrasonic)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	WEE1-IN-5 is a potentWEE1inhibitor with anIC₅₀value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer^[1]. WEE1-IN-5 exhibits an EC₅₀of 188 nM in pCDC2 and an IC₅₀shift for CYP3A4/5^[1]. WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUC_int1324 h.ng/mL and bioavailability of 35% in SD rats^[1].