Sodium Butyrate

32160405

NA.41

Sodium Butyrate has been used:

• to inhibit histone deacetylase (HDAC) and study its effect on fibroblast growth factor 21 (FGF21) expression in liver
• to inhibit deacetylase activity in embryonic stem (ES) cells to determine if the enzymatic activity of the mSin3A-HDAC complex is essential for Nanog expression
• as a reagent during tissue homogenization
• as a supplement in chromatin immunoprecipitation (ChIP) dilution buffer

Sodium Butyrate is a short-chain fatty acid and a histone deacetylase inhibitor. It protects dopaminergic neuronal cells from α-synuclein mediated transcriptional deregulation and DNA damage, maybe by enhancing the expression of DNA-repair genes. Sodium butyrate may promote the production of foreign proteins such as erythropoietin, tissue plasminogen activator, antibody, and nitric oxide synthase in recombinant Chinese hamster ovary (rCHO) cell cultures. But, the higher concentration of sodium butyrate in rCHO cell cultures may also exhibit a cytotoxic effect on cell growth by inducing apoptosis. Sodium Butyrate prevents the growth of cancer cells by downregulating the thioredoxin 1 (Trx1) expression, stimulating reactive oxygen species (ROS) production, and inhibiting cell proliferation and migration of various carcinoma cells including colorectal cancer (CRC).

CH₃CH₂CH₂COONa

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

100

Upstate^®

activity assay: suitable (histone deacetylase (HDAC))

wet ice

1 year at 4°C

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

GHS05

Danger

H314

P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405

Eye Dam. 1 - Skin Corr. 1B

8B - Non-combustible, corrosive hazardous materials

WGK 1