Naftifine Hydrochloride

C₂₁H₂₁N · HCl

323.86

MFCD00059047

329818590

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

200

≥99%

powder

ethanol: soluble 50 mg/mL

Gram-negative bacteria
Gram-positive bacteria
fungi
yeast

cell wall synthesis | interferes
enzyme | inhibits

2-8℃

Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23

1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;

OLUNPKFOFGZHRT-YGCVIUNWSA-N

50, 500 mg in poly bottle

13 - Non Combustible Solids

nwg