Atractylenolide I

C₁₅H₁₈O₂

230.30

MFCD09037395

NA.25

Atractylenolide I is one of the active ingredients of Rhizoma Atractylodes macrocephala which is obtained from the dried root and stem of Atractylodes Macrocephala Koidz. It is a sesquiterpene compound of hydrophobic nature.

Atractylenolide I is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide I may be used and studied as a postitive modulator of GABA-induced chloride currents I(GABA) and as an inhibitor of aromatases. Atractylenolide I may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.

Atractylenolide I has been reported to have an anti-inflammatory activity due to its inhibitory effect on tumor necrosis factor-α (TNF-α) and the production of nitric oxide (NO). It also shows anti-cancer nature, thereby being used in the management of gastric cancer cachexia symptoms. Additionally, it has anti-angiogenic, pro-oxidative and cytotoxic characteristics.
Phytochemical from Traditional Chinese Medicine herbal preparations. Atractylenolide I is an anti-inflammatory that is reported to inhibit angiogenesis.

100

≥98% (HPLC)

powder or crystals

methanol: 1 mg/mL, clear, colorless

2-8℃

C=C1CCC[C@@](C=C2O3)(C)[C@@]1([H])CC2=C(C)C3=O

10 mg in glass bottle
50 mg in poly bottle

11 - Combustible Solids

WGK 3

339.6 °F

170.87 ℃