基因名：

A2ML1

产品别名９�p style="text-indent: 2em;">CPAMD9� OMS� p170� A2ML1� alpha-2-macroglobulin like 1� alpha-2-macroglobulin like 1� alpha-2-macroglobulin-like protein 1� C3 and PZP-like, alpha-2-macroglobulin domain containing 9� α2-巨球蛋白样蛋�?(a2ML1)� α2巨球蛋白样蛋�?�

背景信息９�div style="text-indent: 2em;">alpha-2-Macroglobulin (alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, alpha-2M was characterized as a pan-proteinase inhibitor that was able to “bait� proteinases into cleaving specific peptide sequences on alpha-2M. This interaction induces a conformational change in alpha-2M, thus enabling it to “trap� the proteinase and further inhibit its activity. Subsequently, alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGF beta) in serum is primarily bound to alpha-2M, which renders TGF� inactive. Mutations and deletions in the gene encoding alpha-2M are associated with an increased incidence of Alzheimer's Disease (AD). Alpha-2-macroglobulin-like protein 1 (alpha2ML1) is a related protein that is expressed in the epidermis and may play a role in keratinocyte differentiation.